What is GTF?
- Glucose Tolerance Factor, or GTF consists of trivalent chromium, amino acids and vitamin B.
- The GTF complex exists in every of the human body cells.
- GTF chromium is the cofactor for insulin, therefore stimulates the biological activity of insulin and improve the sensitivity of insulin receptors.
GTF is similar as the key for the cells. It allows glucose from bloodstream smoothly transported into cells and convert into energy. Therefore, GTF helps in metabolism.
The essential of GTF: trivalent chromium
- Chromium is an element that exists in our environment mainly in two forms, hexavalent (Cr 6+).
- The trivalent form, a low toxicity form which is an essential nutrient that found in most foods (Anderson et al., 1997). Examples of foods that contain chromium is banana, whole grain products and broccoli.
- However, the absorption rate of chromium from foods is as low as from 0.3% to 3% only.
- Absorption of Cr3+ from supplements such as chromium picolinate, chromium polynicotinate ranges from 3-4%.
- However, human loses chromium with aging, hence become less sensitive to plasma insulin and ultimately develops impaired glucose tolerance.
- Therefore, normal people can take around 50-200mcg of chromium per day, according to study conducted in US.
Research also shows that GTF plays an important role in regulating one’s plasma glucose level. Supplementation of GTF chromium for 16 weeks significantly reduce fasting blood glucose level by 22% (Pei et al., 2006).
Besides that, chromium supplementation also able to reduce Hemoglobin A1c (HbA1c) level by 0.5-1.1% (Pei et al., 2006; Huang et al., 2018). A reduction of HbA1c by 1% able to reduce the complications of diabetes (Stratton et al., 2000).
- Anderson, R.A., 1997. Chromium as an essential nutrient for humans. Regulatory toxicology and pharmacology, 26(1), pp.S35-S41.
- Huang, H., Chen, G., Dong, Y., Zhu, Y. and Chen, H., 2018. Chromium supplementation for adjuvant treatment of type 2 diabetes mellitus: Results from a pooled analysis. Molecular nutrition & food research, 62(1), p.1700438.
- Pei D et al. 2006. The influence of chromium chloride-containing milk to glycemic control of patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled trial. Metabolism Clinical and Experimental 55:923.